Aaron Ciechanover, M.D., D.SC

Dr. Aaron Ciechanover is a Distinguished Research Professor in the Technion–Israel Institute of Technology in Haifa. Following national service as military physician (1973-1976), he continued his studies to obtain a D.Sc., Technion in 1982. There, as a graduate student with Dr. Avram Hershko, they discovered that covalent attachment of ubiquitin to a target protein signals it for degradation. As a post-doctoral fellow with Dr. Harvey Lodish at the Massachusetts Institute of Technology (MIT), he continued his studies on the ubiquitin system and made additional important discoveries. Over the years, it has become clear that ubiquitin-mediated proteolysis plays major roles in numerous cellular processes, and aberrations in the system underlie the pathogenetic mechanisms of many diseases, among them certain malignancies and neurodegenerative disorders. Consequently, the system has become an important platform for drug development. Among the numerous prizes Ciechanover received are the 2000 Albert Lasker Award, 2003 Israel Prize and the 2004 Nobel Prize (chemistry, shared with Drs. Hershko and Rose). Among many academies, Dr. Ciechanover is member of the Israeli National Academy of Sciences and Humanities, American Academy of Arts and Sciences (Foreign Fellow), American Philosophical Society, U.S. National Academy of Sciences and the Institute of Medicine of the U.S. National Academies (Foreign Associate), and the Russian Academy of Sciences (Foreign Member). He received his M.Sc. and M.D. from Hebrew University in Jerusalem.